14 June 2019The paper is an overview of the main significant advances in the knowledge of brain functioning by modern neuroscience that have contributed to the emergence of neuroeconomics and its rise over the past two decades. These advances are grouped over three non-independent topics referred to as the “emo-rational” brain, “social” brain, and “computational” brain. For each topic, it emphasizes findings considered as critical to the birth and development of neuroeconomics while highlighting some of prominent questions about which knowledge should be improved by future research. In parallel, it shows that the boundaries between neuroeconomics and several recent subfields of cognitive neuroscience, such as affective, social, and more generally, decision neuroscience, are rather porous. It suggests that a greater autonomy of neuroeconomics should perhaps come from the development of studies about more economic policy-oriented concerns. In order to make the paper accessible to a large audience the various neuroscientific notions used are defined and briefly explained. In the same way, for economists not specialized in experimental and behavioral economics, the definition of the main economic models referred to in the text is recalled.